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Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis
Many cancer cells consume glutamine at high rates; counterintuitively, they simultaneously excrete glutamate, the first intermediate in glutamine metabolism. Glutamine consumption has been linked to replenishment of tricarboxylic acid cycle (TCA) intermediates and synthesis of adenosine triphosphate...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229649/ https://www.ncbi.nlm.nih.gov/pubmed/32341162 http://dx.doi.org/10.1073/pnas.1919250117 |