Inverted duplicate DNA sequences increase translocation rates through sequencing nanopores resulting in reduced base calling accuracy

Inverted duplicated DNA sequences are a common feature of structural variants (SVs) and copy number variants (CNVs). Analysis of CNVs containing inverted duplicated DNA sequences using nanopore sequencing identified recurrent aberrant behavior characterized by low confidence, incorrect and missed ba...

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Detalles Bibliográficos
Autores principales: Spealman, Pieter, Burrell, Jaden, Gresham, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229812/
https://www.ncbi.nlm.nih.gov/pubmed/32255181
http://dx.doi.org/10.1093/nar/gkaa206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229812/
https://www.ncbi.nlm.nih.gov/pubmed/32255181
http://dx.doi.org/10.1093/nar/gkaa206

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