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Mechanistic insights into m(6)A modification of U6 snRNA by human METTL16
The N(6)-methyladenosine modification at position 43 (m(6)A43) of U6 snRNA is catalyzed by METTL16, and is important for the 5′-splice site recognition by U6 snRNA during pre-mRNA splicing. Human METTL16 consists of the N-terminal methyltransferase domain (MTD) and the C-terminal vertebrate conserve...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229813/ https://www.ncbi.nlm.nih.gov/pubmed/32266935 http://dx.doi.org/10.1093/nar/gkaa227 |