ATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition

Replication factor C (RFC), a heteropentamer of RFC1-5, loads PCNA onto DNA during replication and repair. Once DNA synthesis has ceased, PCNA must be unloaded. Recent findings assign the uloader role primarily to an RFC-like (RLC) complex, in which the largest RFC subunit, RFC1, has been replaced w...

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Detalles Bibliográficos
Autores principales: Giovannini, Sara, Weller, Marie-Christine, Hanzlíková, Hana, Shiota, Tetsuya, Takeda, Shunichi, Jiricny, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229844/
https://www.ncbi.nlm.nih.gov/pubmed/32297953
http://dx.doi.org/10.1093/nar/gkaa255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229844/
https://www.ncbi.nlm.nih.gov/pubmed/32297953
http://dx.doi.org/10.1093/nar/gkaa255

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