Syntheses and Glycosidase Inhibitory Activities, and in Silico Docking Studies of Pericosine E Analogs Methoxy-Substituted at C6

Inspired by the significant α-glucosidase inhibitory activities of (+)- and (−)-pericosine E, we herein designed and synthesized 16 analogs of these marine natural products bearing a methoxy group instead of a chlorine atom at C6. Four of these compounds exhibited moderate α-glucosidase inhibitory a...

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Detalles Bibliográficos
Autores principales: Usami, Yoshihide, Higuchi, Megumi, Mizuki, Koji, Yamamoto, Mizuki, Kanki, Mao, Nakasone, Chika, Sugimoto, Yuya, Shibano, Makio, Uesawa, Yoshihiro, Nagai, Junko, Yoneyama, Hiroki, Harusawa, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230162/
https://www.ncbi.nlm.nih.gov/pubmed/32326065
http://dx.doi.org/10.3390/md18040221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230162/
https://www.ncbi.nlm.nih.gov/pubmed/32326065
http://dx.doi.org/10.3390/md18040221

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