IMPA2 Downregulation Enhances mTORC1 Activity and Restrains Autophagy Initiation in Metastatic Clear Cell Renal Cell Carcinoma

Although mTOR inhibitors have been approved as first-line therapy for treating metastatic clear cell renal cell carcinoma (ccRCC), the lack of useful markers reduces their therapeutic effectiveness. The objective of this study was to estimate if inositol monophosphatase 2 (IMPA2) downregulation refe...

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Detalles Bibliográficos
Autores principales: Kuei, Chia-Hao, Lin, Hui-Yu, Lee, Hsun-Hua, Lin, Che-Hsuan, Zheng, Jing-Quan, Chen, Kuan-Chou, Lin, Yuan-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230261/
https://www.ncbi.nlm.nih.gov/pubmed/32235551
http://dx.doi.org/10.3390/jcm9040956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230261/
https://www.ncbi.nlm.nih.gov/pubmed/32235551
http://dx.doi.org/10.3390/jcm9040956

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