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Network-Based Single-Cell RNA-Seq Data Imputation Enhances Cell Type Identification

Single-cell RNA sequencing is a powerful technology for obtaining transcriptomes at single-cell resolutions. However, it suffers from dropout events (i.e., excess zero counts) since only a small fraction of transcripts get sequenced in each cell during the sequencing process. This inherent sparsity...

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Detalles Bibliográficos
Autores principales: Zand, Maryam, Ruan, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230610/
https://www.ncbi.nlm.nih.gov/pubmed/32244427
http://dx.doi.org/10.3390/genes11040377