Cargando…

Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications

Background and Objectives: The surgical choice treatment of the breast cancer mostly depends on the stage of the disease. In the last years, breast cancer surgery has moved from being destructive to being more respectful of the anatomical and physiological integrity of the gland. The aim of the brea...

Descripción completa

Detalles Bibliográficos
Autores principales: Metere, Alessio, Fabiani, Elisabetta, Lonardo, Maria Teresa, Giannotti, Domenico, Pace, Daniela, Giacomelli, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230840/
https://www.ncbi.nlm.nih.gov/pubmed/32276470
http://dx.doi.org/10.3390/medicina56040166
_version_ 1783535050391814144
author Metere, Alessio
Fabiani, Elisabetta
Lonardo, Maria Teresa
Giannotti, Domenico
Pace, Daniela
Giacomelli, Laura
author_facet Metere, Alessio
Fabiani, Elisabetta
Lonardo, Maria Teresa
Giannotti, Domenico
Pace, Daniela
Giacomelli, Laura
author_sort Metere, Alessio
collection PubMed
description Background and Objectives: The surgical choice treatment of the breast cancer mostly depends on the stage of the disease. In the last years, breast cancer surgery has moved from being destructive to being more respectful of the anatomical and physiological integrity of the gland. The aim of the breast surgery should be finalized to obtain the best aesthetic and functional results, respecting the principles of oncologic radicality. The present study is a retrospective analysis aimed to evaluate the long-term outcomes of a conservative technique like the nipple-sparing mastectomy. Materials and Methods: We observed 894 patients with a median age of 47.5 years old, underwent nipple-sparing mastectomy between 2002–2017. The data acquired include population and tumor characteristics, patient reconstructive outcomes, including locoregional, regional, and distant metastases; other variables, among nipple–areola complex necrosis and infection were collected. Results: The complications detected were considered as “early” within 1 month later the nipple-sparing mastectomy or “late” after this time. The overall complications rate (early and late) and the overall survival and the relapses detected by this study were comparable with those reported in the literature. In order to identify factors that correlate with complications, either early or later, it has been processed an evaluation of the univariate analysis showing adjuvant chemotherapy as the only predictive factor for late complications, while we encountered no predictors for early complications. Conclusions: The present study adds to the data already present in literature, demonstrating that the nipple-sparing mastectomy is a safe procedure, providing good oncological and aesthetic results in patients carefully selected.
format Online
Article
Text
id pubmed-7230840
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72308402020-05-22 Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications Metere, Alessio Fabiani, Elisabetta Lonardo, Maria Teresa Giannotti, Domenico Pace, Daniela Giacomelli, Laura Medicina (Kaunas) Article Background and Objectives: The surgical choice treatment of the breast cancer mostly depends on the stage of the disease. In the last years, breast cancer surgery has moved from being destructive to being more respectful of the anatomical and physiological integrity of the gland. The aim of the breast surgery should be finalized to obtain the best aesthetic and functional results, respecting the principles of oncologic radicality. The present study is a retrospective analysis aimed to evaluate the long-term outcomes of a conservative technique like the nipple-sparing mastectomy. Materials and Methods: We observed 894 patients with a median age of 47.5 years old, underwent nipple-sparing mastectomy between 2002–2017. The data acquired include population and tumor characteristics, patient reconstructive outcomes, including locoregional, regional, and distant metastases; other variables, among nipple–areola complex necrosis and infection were collected. Results: The complications detected were considered as “early” within 1 month later the nipple-sparing mastectomy or “late” after this time. The overall complications rate (early and late) and the overall survival and the relapses detected by this study were comparable with those reported in the literature. In order to identify factors that correlate with complications, either early or later, it has been processed an evaluation of the univariate analysis showing adjuvant chemotherapy as the only predictive factor for late complications, while we encountered no predictors for early complications. Conclusions: The present study adds to the data already present in literature, demonstrating that the nipple-sparing mastectomy is a safe procedure, providing good oncological and aesthetic results in patients carefully selected. MDPI 2020-04-08 /pmc/articles/PMC7230840/ /pubmed/32276470 http://dx.doi.org/10.3390/medicina56040166 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Metere, Alessio
Fabiani, Elisabetta
Lonardo, Maria Teresa
Giannotti, Domenico
Pace, Daniela
Giacomelli, Laura
Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications
title Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications
title_full Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications
title_fullStr Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications
title_full_unstemmed Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications
title_short Nipple-Sparing Mastectomy Long-Term Outcomes: Early and Late Complications
title_sort nipple-sparing mastectomy long-term outcomes: early and late complications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230840/
https://www.ncbi.nlm.nih.gov/pubmed/32276470
http://dx.doi.org/10.3390/medicina56040166
work_keys_str_mv AT meterealessio nipplesparingmastectomylongtermoutcomesearlyandlatecomplications
AT fabianielisabetta nipplesparingmastectomylongtermoutcomesearlyandlatecomplications
AT lonardomariateresa nipplesparingmastectomylongtermoutcomesearlyandlatecomplications
AT giannottidomenico nipplesparingmastectomylongtermoutcomesearlyandlatecomplications
AT pacedaniela nipplesparingmastectomylongtermoutcomesearlyandlatecomplications
AT giacomellilaura nipplesparingmastectomylongtermoutcomesearlyandlatecomplications