MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II

The capacity of Topoisomerase II (Topo II) to remove DNA catenations that arise after replication is essential to ensure faithful chromosome segregation. Topo II activity is monitored during G2 by a specific checkpoint pathway that delays entry into mitosis until the chromosomes are properly decaten...

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Detalles Bibliográficos
Autores principales: Arroyo, María, Sánchez, Antonio, Cañuelo, Ana, Heredia-Molina, Rosalía F., Martínez-Molina, Eduardo, Clarke, Duncan J., Marchal, Juan Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231051/
https://www.ncbi.nlm.nih.gov/pubmed/32276518
http://dx.doi.org/10.3390/genes11040406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231051/
https://www.ncbi.nlm.nih.gov/pubmed/32276518
http://dx.doi.org/10.3390/genes11040406

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