Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity

This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release wa...

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Detalles Bibliográficos
Autores principales: Alhakamy, Nabil A., Fahmy, Usama A., Ahmed, Osama A. A., Caruso, Giuseppe, Caraci, Filippo, Asfour, Hani Z., Bakhrebah, Muhammed A., N. Alomary, Mohammad, Abdulaal, Wesam H., Okbazghi, Solomon Z., Abdel-Naim, Ashraf B., Eid, Basma G., Aldawsari, Hibah M., Kurakula, Mallesh, Mohamed, Amir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231066/
https://www.ncbi.nlm.nih.gov/pubmed/32344610
http://dx.doi.org/10.3390/md18040226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231066/
https://www.ncbi.nlm.nih.gov/pubmed/32344610
http://dx.doi.org/10.3390/md18040226

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