A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions

Transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress. Inhibitors of Keap1-Nrf2 interaction are promising in oxidative str...

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Detalles Bibliográficos
Autores principales: Lu, Mengchen, Zhang, Xian, Zhao, Jing, You, Qidong, Jiang, Zhengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231841/
https://www.ncbi.nlm.nih.gov/pubmed/32422540
http://dx.doi.org/10.1016/j.redox.2020.101565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231841/
https://www.ncbi.nlm.nih.gov/pubmed/32422540
http://dx.doi.org/10.1016/j.redox.2020.101565

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