Realising the therapeutic potential of neuroactive steroid modulators of the GABA(A) receptor

In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABA(A) receptor (GABA(A)R). These reports were followed by the discovery that such steroids may be synthesised not only in...

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Detalles Bibliográficos
Autores principales: Belelli, Delia, Hogenkamp, Derk, Gee, Kelvin W., Lambert, Jeremy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Articles from the Special Issue on Allopregnanolone role in the neurobiology of stress and mood disorders; Edited by Graziano Pinna
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231973/
https://www.ncbi.nlm.nih.gov/pubmed/32435660
http://dx.doi.org/10.1016/j.ynstr.2019.100207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231973/
https://www.ncbi.nlm.nih.gov/pubmed/32435660
http://dx.doi.org/10.1016/j.ynstr.2019.100207

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