High Throughput Screening of FDA-Approved Drug Library Reveals the Compounds that Promote IRF3-Mediated Pro-Apoptotic Pathway Inhibit Virus Replication

Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt...

Descripción completa

Detalles Bibliográficos
Autores principales: Glanz, Anna, Chawla, Karan, Fabry, Stephanie, Subramanian, Gayatri, Garcia, Julie, Jay, Bryanna, Ciricillo, Jacob, Chakravarti, Ritu, Taylor, R. Travis, Chattopadhyay, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232324/
https://www.ncbi.nlm.nih.gov/pubmed/32295140
http://dx.doi.org/10.3390/v12040442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232324/
https://www.ncbi.nlm.nih.gov/pubmed/32295140
http://dx.doi.org/10.3390/v12040442

Ejemplares similares