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High Throughput Screening of FDA-Approved Drug Library Reveals the Compounds that Promote IRF3-Mediated Pro-Apoptotic Pathway Inhibit Virus Replication
Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt...
Autores principales: | Glanz, Anna, Chawla, Karan, Fabry, Stephanie, Subramanian, Gayatri, Garcia, Julie, Jay, Bryanna, Ciricillo, Jacob, Chakravarti, Ritu, Taylor, R. Travis, Chattopadhyay, Saurabh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232324/ https://www.ncbi.nlm.nih.gov/pubmed/32295140 http://dx.doi.org/10.3390/v12040442 |
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