Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer

Defects in DNA damage repair may cause genome instability and cancer development. The tumor suppressor gene p53 regulates cell cycle arrest to allow time for DNA repair. The oncoprotein mouse double minute 2 (MDM2) promotes cell survival, proliferation, invasion, and therapeutic resistance in many t...

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Detalles Bibliográficos
Autores principales: Li, Wen, Peng, Xinhao, Lang, Jinyi, Xu, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232544/
https://www.ncbi.nlm.nih.gov/pubmed/32477121
http://dx.doi.org/10.3389/fphar.2020.00631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232544/
https://www.ncbi.nlm.nih.gov/pubmed/32477121
http://dx.doi.org/10.3389/fphar.2020.00631

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