Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

AIMS: Small conductance Ca(2+)-activated K(+) channels (SK channels, K(Ca)2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of K(Ca)2 channels that is currently in clinical development for treatment of AF. The aim of this study is to present the ele...

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Detalles Bibliográficos
Autores principales: Bentzen, Bo Hjorth, Bomholtz, Sofia Hammami, Simó-Vicens, Rafel, Folkersen, Lasse, Abildgaard, Lea, Speerschneider, Tobias, Muthukumarasamy, Kalai Mangai, Edvardsson, Nils, Sørensen, Ulrik S., Grunnet, Morten, Diness, Jonas Goldin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232560/
https://www.ncbi.nlm.nih.gov/pubmed/32477117
http://dx.doi.org/10.3389/fphar.2020.00610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232560/
https://www.ncbi.nlm.nih.gov/pubmed/32477117
http://dx.doi.org/10.3389/fphar.2020.00610

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