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Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease
Sleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation and thalamocortical sleep spindles in mice expressing the p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) gene, one of the most common genetic for...
Autores principales: | Crown, Lindsey M., Bartlett, Mitchell J., Wiegand, Jean-Paul L., Eby, Allison J., Monroe, Emily J., Gies, Kathleen, Wohlford, Luke, Fell, Matthew J., Falk, Torsten, Cowen, Stephen L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232828/ https://www.ncbi.nlm.nih.gov/pubmed/32477237 http://dx.doi.org/10.3389/fneur.2020.00324 |
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