Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution

BACKGROUND: “Quantile-dependent expressivity” refers to a genetic effect that is dependent upon whether the phenotype (e.g., spirometric data) is high or low relative to its population distribution. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV(1)), and the FEV(1)/FVC ratio...

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Detalles Bibliográficos
Autor principal: Williams, Paul T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233273/
https://www.ncbi.nlm.nih.gov/pubmed/32461834
http://dx.doi.org/10.7717/peerj.9145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233273/
https://www.ncbi.nlm.nih.gov/pubmed/32461834
http://dx.doi.org/10.7717/peerj.9145

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