Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching

Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin heavy (IgH) locus. During CSR, transcription through specific switch (S) regions and processing of non-coding germline transcripts (GLTs) ar...

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Detalles Bibliográficos
Autores principales: Marchalot, Anne, Ashi, Mohamad Omar, Lambert, Jean-Marie, Carrion, Claire, Lecardeur, Sandrine, Srour, Nivine, Delpy, Laurent, Le Pennec, Soazig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233311/
https://www.ncbi.nlm.nih.gov/pubmed/32477332
http://dx.doi.org/10.3389/fimmu.2020.00780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233311/
https://www.ncbi.nlm.nih.gov/pubmed/32477332
http://dx.doi.org/10.3389/fimmu.2020.00780

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