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T215. THE ANTIPSYCHOTIC ACTION OF HALOPERIDOL IN PSYCHOTIC-LIKE RATS REQUIRES PRESYNAPTIC VESICULAR ACCUMULATION

BACKGROUND: The therapeutic effects of antipsychotic drugs (APDs) are mainly attributed to their post synaptic inhibitory functions on the dopamine D2 receptor, which however, cannot explain the delayed onset of full therapeutic efficacy. It was previously shown that APDs accumulate in presynaptic v...

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Detalles Bibliográficos
Autores principales: Müller, Christian, Weiss, Eva-Maria, Hellmann, Jan, Dahlmanns, Jana, Kalinichenko, Liubov, Alzheimer, Christian, Löber, Stefan, Hübner, Harald, Kornhuber, Johannes, Gmeiner, Peter, Grömer, Teja, Uzuneser, Taygun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234311/
http://dx.doi.org/10.1093/schbul/sbaa029.775