Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex. How the PKA-C/PKI complex assembles and recognizes...

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Detalles Bibliográficos
Autores principales: Olivieri, Cristina, Wang, Yingjie, Li, Geoffrey C, V S, Manu, Kim, Jonggul, Stultz, Benjamin R, Neibergall, Matthew, Porcelli, Fernando, Muretta, Joseph M, Thomas, David DT, Gao, Jiali, Blumenthal, Donald K, Taylor, Susan S, Veglia, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234811/
https://www.ncbi.nlm.nih.gov/pubmed/32338601
http://dx.doi.org/10.7554/eLife.55607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234811/
https://www.ncbi.nlm.nih.gov/pubmed/32338601
http://dx.doi.org/10.7554/eLife.55607

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