Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity

Preclinical models of Alzheimer’s disease (AD) suggest APOE modulates brain function in structures vulnerable to AD pathophysiology. However, genome-wide association studies now demonstrate that AD risk is shaped by a broader polygenic architecture, estimated via polygenic risk scoring (AD-PRS). Des...

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Detalles Bibliográficos
Autores principales: Chandler, Hannah L., Hodgetts, Carl J., Caseras, Xavier, Murphy, Kevin, Lancaster, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234982/
https://www.ncbi.nlm.nih.gov/pubmed/31896120
http://dx.doi.org/10.1038/s41386-019-0595-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234982/
https://www.ncbi.nlm.nih.gov/pubmed/31896120
http://dx.doi.org/10.1038/s41386-019-0595-1

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