HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

DNA damage contributes to brain aging and neurodegenerative diseases. However, the factors stimulating DNA repair to stave off functional decline remain obscure. We show that HDAC1 modulates OGG1-initated 8-oxoguanine (8-oxoG) repair in the brain. HDAC1-deficient mice display age-associated DNA dama...

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Detalles Bibliográficos
Autores principales: Pao, Ping-Chieh, Patnaik, Debasis, Watson, L. Ashley, Gao, Fan, Pan, Ling, Wang, Jun, Adaikkan, Chinnakkaruppan, Penney, Jay, Cam, Hugh P., Huang, Wen-Chin, Pantano, Lorena, Lee, Audrey, Nott, Alexi, Phan, Trongha X., Gjoneska, Elizabeta, Elmsaouri, Sara, Haggarty, Stephen J., Tsai, Li-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235043/
https://www.ncbi.nlm.nih.gov/pubmed/32424276
http://dx.doi.org/10.1038/s41467-020-16361-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235043/
https://www.ncbi.nlm.nih.gov/pubmed/32424276
http://dx.doi.org/10.1038/s41467-020-16361-y

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