Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

Histone ubiquitination plays an important role in the DNA damage response (DDR) pathway. RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage and promotes the accrual of downstream repair factors at damaged chromatin. Here, we report that RNF168 ubiquitinates the no...

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Detalles Bibliográficos
Autores principales: Kelliher, Jessica L., West, Kirk L., Gong, Qingguo, Leung, Justin W. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235047/
https://www.ncbi.nlm.nih.gov/pubmed/32424115
http://dx.doi.org/10.1038/s41467-020-16307-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235047/
https://www.ncbi.nlm.nih.gov/pubmed/32424115
http://dx.doi.org/10.1038/s41467-020-16307-4

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