Cargando…

Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

Histone ubiquitination plays an important role in the DNA damage response (DDR) pathway. RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage and promotes the accrual of downstream repair factors at damaged chromatin. Here, we report that RNF168 ubiquitinates the no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelliher, Jessica L., West, Kirk L., Gong, Qingguo, Leung, Justin W. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235047/ https://www.ncbi.nlm.nih.gov/pubmed/32424115 http://dx.doi.org/10.1038/s41467-020-16307-4

Ejemplares similares

UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair
por: Lee, Seong-Ok, et al.
Publicado: (2023)

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase
por: Gatti, Marco, et al.
Publicado: (2012)

BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response
por: Zhao, Hongchang, et al.
Publicado: (2014)

Calling RNF168 to action
por: Nowsheen, Somaira, et al.
Publicado: (2018)

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A
por: Mattiroli, Francesca, et al.
Publicado: (2014)

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment
por: Kongsema, M, et al.
Publicado: (2016)

Erratum: The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A
por: Mattiroli, Francesca, et al.
Publicado: (2014)

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway
por: Mandemaker, I. K., et al.
Publicado: (2017)

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage
por: Kitevski-LeBlanc, Julianne, et al.
Publicado: (2017)

RNF126 Quenches RNF168 Function in the DNA Damage Response
por: Zhang, Lianzhong, et al.
Publicado: (2018)

Emerging Roles of RNF168 in Tumor Progression
por: Xie, Tianyuan, et al.
Publicado: (2023)

L3MBTL2 orchestrates ubiquitin signaling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage
por: Nowsheen, Somaira, et al.
Publicado: (2018)

Structural basis of specific H2A K13/K15 ubiquitination by RNF168
por: Horn, Velten, et al.
Publicado: (2019)

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX
por: Pinato, Sabrina, et al.
Publicado: (2009)

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168
por: Kocyłowski, Maciej K, et al.
Publicado: (2015)

The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining
por: Chen, Bo-Ruei, et al.
Publicado: (2021)

Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival
por: Kizilors, Aytug, et al.
Publicado: (2017)

Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling
por: Leung, Justin W., et al.
Publicado: (2014)

Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice
por: Nakada, Shinichiro
Publicado: (2016)

Clinical and Biological Manifestation of RNF168 Deficiency in Two Polish Siblings
por: Pietrucha, Barbara, et al.
Publicado: (2017)

RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy
por: Chang, Hae Ryung
Publicado: (2023)

Extension of the experiment T 165 + T 168
por: CERN. Geneva. Track Chamber Committee
Publicado: (1972)

RNF168 facilitates oestrogen receptor ɑ transcription and drives breast cancer proliferation
por: Liu, Zhenhua, et al.
Publicado: (2018)

The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair
por: Qiu, Lingyu, et al.
Publicado: (2023)

Regulation of 53BP1 Protein Stability by RNF8 and RNF168 Is Important for Efficient DNA Double-Strand Break Repair
por: Hu, Yiheng, et al.
Publicado: (2014)

Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites
por: Bartocci, Cristina, et al.
Publicado: (2013)

RNF168 facilitates proliferation and invasion of esophageal carcinoma, possibly via stabilizing STAT1
por: Yu, Na, et al.
Publicado: (2018)

Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis
por: Zou, Luxi, et al.
Publicado: (2023)

The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function
por: Okamoto, Takumi, et al.
Publicado: (2020)

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
por: Guturi, Kiran Kumar Naidu, et al.
Publicado: (2016)

RNF11 at the Crossroads of Protein Ubiquitination
por: Mattioni, Anna, et al.
Publicado: (2020)

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
por: Khateb, Ali, et al.
Publicado: (2021)

Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168
por: Takahashi, Tomio S., et al.
Publicado: (2018)

A Novel Reciprocal Crosstalk between RNF168 and PARP1 to Regulate DNA Repair Processes
por: Kim, Jae Jin, et al.
Publicado: (2018)

MRE11 and UBR5 Co-Operate to Suppress RNF168-Mediated Fusion of Dysfunctional Telomeres
por: Tang, Yongjian, et al.
Publicado: (2021)

Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-Strand Break Repair
por: Zhang, Fan, et al.
Publicado: (2014)

The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis
por: Wegwitz, Florian, et al.
Publicado: (2020)

Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
por: Zong, Dali, et al.
Publicado: (2015)

The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168
por: Xie, Xiaoduo, et al.
Publicado: (2018)

Ectopic RNF168 expression promotes break-induced replication-like DNA synthesis at stalled replication forks
por: Krais, John J, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_brlr1dpsuh4jnbacu858ahgr92