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Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutag...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235221/ https://www.ncbi.nlm.nih.gov/pubmed/32424320 http://dx.doi.org/10.1038/s41467-020-16065-3 |