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Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice

Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutag...

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Detalles Bibliográficos
Autores principales:	Srifa, Waracharee, Kosaric, Nina, Amorin, Alvaro, Jadi, Othmane, Park, Yujin, Mantri, Sruthi, Camarena, Joab, Gurtner, Geoffrey C., Porteus, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235221/ https://www.ncbi.nlm.nih.gov/pubmed/32424320 http://dx.doi.org/10.1038/s41467-020-16065-3

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