Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice

In preceding efforts, we demonstrated that antibiotic (ABX) cocktail-mediated perturbations of the gut microbiome in two independent transgenic lines, termed APP(SWE)/PS1(ΔE9) and APPPS1-21, leads to a reduction in Aβ deposition in male mice. To determine whether these observed reductions of cerebra...

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Detalles Bibliográficos
Autores principales: Dodiya, Hemraj B., Frith, Mary, Sidebottom, Ashley, Cao, Yajun, Koval, Jason, Chang, Eugene, Sisodia, Sangram S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235236/
https://www.ncbi.nlm.nih.gov/pubmed/32424118
http://dx.doi.org/10.1038/s41598-020-64797-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235236/
https://www.ncbi.nlm.nih.gov/pubmed/32424118
http://dx.doi.org/10.1038/s41598-020-64797-5

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