A Cas9 with PAM recognition for adenine dinucleotides

CRISPR-associated (Cas) DNA-endonucleases are remarkably effective tools for genome engineering, but have limited target ranges due to their protospacer adjacent motif (PAM) requirements. We demonstrate a critical expansion of the targetable sequence space for a type II-A CRISPR-associated enzyme th...

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Detalles Bibliográficos
Autores principales: Chatterjee, Pranam, Lee, Jooyoung, Nip, Lisa, Koseki, Sabrina R. T., Tysinger, Emma, Sontheimer, Erik J., Jacobson, Joseph M., Jakimo, Noah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235249/
https://www.ncbi.nlm.nih.gov/pubmed/32424114
http://dx.doi.org/10.1038/s41467-020-16117-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235249/
https://www.ncbi.nlm.nih.gov/pubmed/32424114
http://dx.doi.org/10.1038/s41467-020-16117-8

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