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α-Synuclein Negatively Regulates Nurr1 Expression Through NF-κB-Related Mechanism

The nuclear receptor-related 1 protein (Nurr1) is critical for the development and survival of midbrain dopamine neurons that are predominantly affected and progressively degenerated in Parkinson’s disease (PD). The expression level of Nurr1 has been proposed to be modulated by α-synuclein (α-SYN),...

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Detalles Bibliográficos
Autores principales: Jia, Congcong, Qi, Hongqian, Cheng, Cheng, Wu, Xuefei, Yang, Zhaofei, Cai, Huaibin, Chen, Sheng, Le, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235291/
https://www.ncbi.nlm.nih.gov/pubmed/32477062
http://dx.doi.org/10.3389/fnmol.2020.00064