Cargando…
α-Synuclein Negatively Regulates Nurr1 Expression Through NF-κB-Related Mechanism
The nuclear receptor-related 1 protein (Nurr1) is critical for the development and survival of midbrain dopamine neurons that are predominantly affected and progressively degenerated in Parkinson’s disease (PD). The expression level of Nurr1 has been proposed to be modulated by α-synuclein (α-SYN),...
Autores principales: | Jia, Congcong, Qi, Hongqian, Cheng, Cheng, Wu, Xuefei, Yang, Zhaofei, Cai, Huaibin, Chen, Sheng, Le, Weidong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235291/ https://www.ncbi.nlm.nih.gov/pubmed/32477062 http://dx.doi.org/10.3389/fnmol.2020.00064 |
Ejemplares similares
-
Alterations of NURR1 and Cytokines in the Peripheral Blood Mononuclear Cells: Combined Biomarkers for Parkinson’s Disease
por: Li, Tianbai, et al.
Publicado: (2018) -
Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates
por: Zhang, Feng, et al.
Publicado: (2017) -
α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1
por: Jia, Congcong, et al.
Publicado: (2021) -
The role of NURR1 in metabolic abnormalities of Parkinson’s disease
por: Al-Nusaif, Murad, et al.
Publicado: (2022) -
Nurr1 repression mediates cardinal features of Parkinson’s disease in α-synuclein transgenic mice
por: Argyrofthalmidou, Maria, et al.
Publicado: (2021)