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Circulating sclerostin is associated with bone mineral density independent of HIV-serostatus

BACKGROUND: Low bone mineral density (BMD) is commonly observed in people living with HIV (PLWH), however the cause for this BMD loss remains unclear. Sclerostin, a bone-derived antagonist to the Wnt/β-catenin-pathway, suppresses bone remodeling and is positively associated with BMD. The goal of the...

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Detalles Bibliográficos
Autores principales: Ross, Ryan D., Sharma, Anjali, Shi, Qiuhu, Hoover, Donald R., Weber, Kathleen M., Tien, Phyllis C., French, Audrey L., Al-Harthi, Lena, Yin, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235609/
https://www.ncbi.nlm.nih.gov/pubmed/32455152
http://dx.doi.org/10.1016/j.bonr.2020.100279