Cargando…

PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels

Multiple sclerosis (MS) is an autoimmune disease in which activated lymphocytes affect the central nervous system. Increase of reactive oxygen species (ROS), impairment of mitochondria-mediated apoptosis and mitochondrial alterations have been reported in peripheral lymphocytes of MS patients. Mitoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Rasmo, Domenico, Ferretta, Anna, Russo, Silvia, Ruggieri, Maddalena, Lasorella, Piergiorgio, Paolicelli, Damiano, Trojano, Maria, Signorile, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235786/ https://www.ncbi.nlm.nih.gov/pubmed/32290388 http://dx.doi.org/10.3390/biomedicines8040085

Ejemplares similares

Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics
por: Signorile, Anna, et al.
Publicado: (2020)

Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy
por: Ruggieri, Maddalena, et al.
Publicado: (2020)

Mitochondrial Dynamics of Proximal Tubular Epithelial Cells in Nephropathic Cystinosis
por: De Rasmo, Domenico, et al.
Publicado: (2019)

Mitochondrial Complex I, a Possible Sensible Site of cAMP Pathway in Aging
por: Signorile, Anna, et al.
Publicado: (2023)

Resveratrol Treatment in Human Parkin-Mutant Fibroblasts Modulates cAMP and Calcium Homeostasis Regulating the Expression of Mitochondria-Associated Membranes Resident Proteins
por: Signorile, Anna, et al.
Publicado: (2021)

Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts
por: Tanzarella, Paola, et al.
Publicado: (2019)

Beneficial effects of SS-31 peptide on cardiac mitochondrial dysfunction in tafazzin knockdown mice
por: Russo, Silvia, et al.
Publicado: (2022)

Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases
por: Signorile, Anna, et al.
Publicado: (2019)

Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics
por: De Rasmo, Domenico, et al.
Publicado: (2023)

Longitudinal Evaluation of Serum MOG-IgG and AQP4-IgG Antibodies in NMOSD by a Semiquantitative Ratiometric Method
por: Bollo, Luca, et al.
Publicado: (2021)

Human Ovarian Cancer Tissue Exhibits Increase of Mitochondrial Biogenesis and Cristae Remodeling
por: Signorile, Anna, et al.
Publicado: (2019)

Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 in Manganese-Induced Apoptosis
por: Alaimo, Agustina, et al.
Publicado: (2014)

Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis
por: Paolicelli, Damiano, et al.
Publicado: (2009)

cAMP/PKA Signaling Modulates Mitochondrial Supercomplex Organization
por: Signorile, Anna, et al.
Publicado: (2022)

Mitochondria Deregulations in Cancer Offer Several Potential Targets of Therapeutic Interventions
por: Musicco, Clara, et al.
Publicado: (2023)

PLA/PHB Blends: Biocompatibilizer Effects
por: D’Anna, Alessandra, et al.
Publicado: (2019)

A case report of late‐onset atypical Hemolytic Uremic Syndrome during interferon beta in multiple sclerosis: Open issues in literature review
por: Parisi, Mosè, et al.
Publicado: (2020)

Interdisciplinary approach to opportunistic infections: staphylococcal meningitis in a patient with multiple sclerosis on treatment with dimethyl fumarate
por: Bollo, Luca, et al.
Publicado: (2022)

Real-Life Experience of the Effects of Cladribine Tablets on Lymphocyte Subsets and Serum Neurofilament Light Chain Levels in Relapsing Multiple Sclerosis Patients
por: Paolicelli, Damiano, et al.
Publicado: (2022)

PHB production from cellobiose with Saccharomyces cerevisiae
por: Ylinen, Anna, et al.
Publicado: (2022)

Examination of PHB Depolymerases in Ralstonia eutropha: Further Elucidation of the Roles of Enzymes in PHB Homeostasis
por: Brigham, Christopher J, et al.
Publicado: (2012)

A Closer Look on the Polyhydroxybutyrate- (PHB-) Negative Phenotype of Ralstonia eutropha PHB(-)4
por: Raberg, Matthias, et al.
Publicado: (2014)

Long-term comparative analysis of no evidence of disease activity (NEDA-3) status between multiple sclerosis patients treated with natalizumab and fingolimod for up to 4 years
por: Guerra, Tommaso, et al.
Publicado: (2021)

Opa: up and running
por: Binsztok, Henri, et al.
Publicado: (2013)

Novel Extracellular PHB Depolymerase from Streptomyces ascomycinicus: PHB Copolymers Degradation in Acidic Conditions
por: García-Hidalgo, Javier, et al.
Publicado: (2013)

Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling
por: Zhang, Kaina, et al.
Publicado: (2023)

Signs of Deregulated Gene Expression Are Present in Both CD14(+) and CD14(-) PBMC From Non-Obese Men With Family History of T2DM
por: Koc, Michal, et al.
Publicado: (2021)

Processability and Mechanical Properties of Thermoplastic Polylactide/Polyhydroxybutyrate (PLA/PHB) Bioblends
por: Olejnik, Olga, et al.
Publicado: (2021)

Resveratrol Modulation of Protein Expression in parkin-Mutant Human Skin Fibroblasts: A Proteomic Approach
por: Vergara, Daniele, et al.
Publicado: (2017)

The Growth of 3T3 Fibroblasts on PHB, PLA and PHB/PLA Blend Films at Different Stages of Their Biodegradation In Vitro
por: Zhuikov, Vsevolod A., et al.
Publicado: (2020)

Exploiting the Physicochemical and Antimicrobial Properties of PHB/PEG and PHB/PEG/ALG-e Blends Loaded with Ag Nanoparticles
por: da Silva, Mário R. P., et al.
Publicado: (2022)

Lymphocyte Count and Body Mass Index as Biomarkers of Early Treatment Response in a Multiple Sclerosis Dimethyl Fumarate-Treated Cohort
por: Manni, Alessia, et al.
Publicado: (2019)

A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis
por: Zhang, Juanjuan, et al.
Publicado: (2017)

Construction of Opa-Positive and Opa-Negative Strains of Neisseria meningitidis to Evaluate a Novel Meningococcal Vaccine
por: Sadarangani, Manish, et al.
Publicado: (2012)

Cyanobacterial Polyhydroxybutyrate (PHB): Screening, Optimization and Characterization
por: Ansari, Sabbir, et al.
Publicado: (2016)

Drug Release Kinetics of Electrospun PHB Meshes
por: Kundrat, Vojtech, et al.
Publicado: (2019)

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy
por: Celestini, Valentina, et al.
Publicado: (2018)

OPA1’s shortcut to mitochondrial fission
por: Short, Ben
Publicado: (2014)

Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects
por: Bentayeb, Hafidha, et al.
Publicado: (2019)

Finding a Benign Plasticizer to Enhance the Microbial Degradation of Polyhydroxybutyrate (PHB) Evaluated by PHB Degrader Microbulbifer sp. SOL66
por: Cho, Jang Yeon, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_np968odbf8tl53gubvk469uqig