Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic parameters (PK) of several CYP3A substrates. We included 251 healthy volunteers who received a single dose of ambrisentan, atorva...

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Detalles Bibliográficos
Autores principales: Saiz-Rodríguez, Miriam, Almenara, Susana, Navares-Gómez, Marcos, Ochoa, Dolores, Román, Manuel, Zubiaur, Pablo, Koller, Dora, Santos, María, Mejía, Gina, Borobia, Alberto M., Rodríguez-Antona, Cristina, Abad-Santos, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235792/
https://www.ncbi.nlm.nih.gov/pubmed/32331352
http://dx.doi.org/10.3390/biomedicines8040094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235792/
https://www.ncbi.nlm.nih.gov/pubmed/32331352
http://dx.doi.org/10.3390/biomedicines8040094

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