Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells

With the increasing resistance of bacteria to current antibiotics, novel compounds are urgently needed to treat bacterial infections. Streptozotocin (STZ) is a natural product that has broad-spectrum antibiotic activity, albeit with limited use because of its toxicity to pancreatic β cells. In an at...

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Detalles Bibliográficos
Autores principales: Zhang, Ji, Yakovlieva, Liubov, de Haan, Bart J., de Vos, Paul, Minnaard, Adriaan J., Witte, Martin D., Walvoort, Marthe T. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235802/
https://www.ncbi.nlm.nih.gov/pubmed/32326389
http://dx.doi.org/10.3390/antibiotics9040182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235802/
https://www.ncbi.nlm.nih.gov/pubmed/32326389
http://dx.doi.org/10.3390/antibiotics9040182

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