Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant Staphylococcus aureus (S. aureus). In S. aureus, BPL is a bifunctional protein responsible for enzymatic biotinylation of two biotin-dependent enzymes, as well as serving...

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Detalles Bibliográficos
Autores principales: Hayes, Andrew J., Satiaputra, Jiulia, Sternicki, Louise M., Paparella, Ashleigh S., Feng, Zikai, Lee, Kwang J., Blanco-Rodriguez, Beatriz, Tieu, William, Eijkelkamp, Bart A., Shearwin, Keith E., Pukala, Tara L., Abell, Andrew D., Booker, Grant W., Polyak, Steven W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235819/
https://www.ncbi.nlm.nih.gov/pubmed/32268615
http://dx.doi.org/10.3390/antibiotics9040165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235819/
https://www.ncbi.nlm.nih.gov/pubmed/32268615
http://dx.doi.org/10.3390/antibiotics9040165

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