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Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant Staphylococcus aureus (S. aureus). In S. aureus, BPL is a bifunctional protein responsible for enzymatic biotinylation of two biotin-dependent enzymes, as well as serving...

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Detalles Bibliográficos
Autores principales:	Hayes, Andrew J., Satiaputra, Jiulia, Sternicki, Louise M., Paparella, Ashleigh S., Feng, Zikai, Lee, Kwang J., Blanco-Rodriguez, Beatriz, Tieu, William, Eijkelkamp, Bart A., Shearwin, Keith E., Pukala, Tara L., Abell, Andrew D., Booker, Grant W., Polyak, Steven W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235819/ https://www.ncbi.nlm.nih.gov/pubmed/32268615 http://dx.doi.org/10.3390/antibiotics9040165

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