Ion-Channel modulator TH1177 reduces glomerular injury and serum creatinine in chronic mesangial proliferative disease in rats

BACKGROUND: T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by a study of the non-selective TTCC inhibitor TH1177 in a chronic model of prolif...

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Detalles Bibliográficos
Autores principales: Cove-Smith, Andrea, Sharpe, Claire C., Shattock, Michael J., Hendry, Bruce M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236127/
https://www.ncbi.nlm.nih.gov/pubmed/32429914
http://dx.doi.org/10.1186/s12882-020-01842-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236127/
https://www.ncbi.nlm.nih.gov/pubmed/32429914
http://dx.doi.org/10.1186/s12882-020-01842-5

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