Cargando…

Ion-Channel modulator TH1177 reduces glomerular injury and serum creatinine in chronic mesangial proliferative disease in rats

BACKGROUND: T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by a study of the non-selective TTCC inhibitor TH1177 in a chronic model of prolif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cove-Smith, Andrea, Sharpe, Claire C., Shattock, Michael J., Hendry, Bruce M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236127/ https://www.ncbi.nlm.nih.gov/pubmed/32429914 http://dx.doi.org/10.1186/s12882-020-01842-5

Ejemplares similares

Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1
por: Pandi, Sudha Priya Soundara, et al.
Publicado: (2022)

In creatinine kinetics, the glomerular filtration rate always moves the serum creatinine in the opposite direction
por: Chen, Sheldon, et al.
Publicado: (2021)

Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation
por: Thomas, Haryana Y., et al.
Publicado: (2022)

Retraction to 10.1177/1758835920922055
Publicado: (2023)

Editorial: Interactions Between Podocytes, Mesangial Cells, and Glomerular Endothelial Cells in Glomerular Diseases
por: Imig, John D., et al.
Publicado: (2022)

Warfarin-Related Nephropathy Manifested as Diffuse Mesangial Proliferative Glomerulonephritis
por: Acquah, Frederick, et al.
Publicado: (2022)

A Case of Mesangial Proliferative Nephritis Caused by Slow Cryoglobulin
por: Hashimoto, Seiji, et al.
Publicado: (2023)

Comparison of Jaffe Method and Enzymatic Method at Measuring Serum Creatinine Level, Creatinine Clearance and Estimated Glomerular Filtration Rate
por: Osmic–Husni, Alma, et al.
Publicado: (2023)

Serum Cystatin-C Is Not Superior to Serum Creatinine in Predicting Glomerular Filtration Rate in Cirrhotic Patients
por: Nasseri-Moghaddam, Siavosh, et al.
Publicado: (2013)

The synthetic triterpenoid, RTA405, increases glomerular filtration rate and reduces angiotensin II-induced contraction of glomerular mesangial cells
por: Ding, Yanfeng, et al.
Publicado: (2012)

AngII-induced glomerular mesangial cell proliferation inhibited by losartan via changes in intracellular calcium ion concentration
por: Qiu, Guoying, et al.
Publicado: (2013)

Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians
por: Lopes, Marcelo B, et al.
Publicado: (2013)

Serum creatinine and estimated glomerular filtration rates in HIV positive and negative adults in Ethiopia
por: Yilma, Daniel, et al.
Publicado: (2019)

Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin α5 in the glomerular basement membrane
por: Kikkawa, Yamato, et al.
Publicado: (2003)

Serum creatinine and cystatin C‐based estimates of glomerular filtration rate are misleading in acute heart failure
por: Swolinsky, Jutta S., et al.
Publicado: (2021)

Effect of recombinant Hepatitis B virus on human glomerular mesangial cell apoptosis
por: Wang, Yiguo, et al.
Publicado: (2014)

Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival
por: Phua, Yu Leng, et al.
Publicado: (2015)

NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy
por: Li, Xue, et al.
Publicado: (2022)

Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine
por: Delanaye, Pierre, et al.
Publicado: (2014)

Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?
por: Rabelo, Nícollas Nunes, et al.
Publicado: (2022)

Estimating Glomerular Filtration Rate from Serum Myo-Inositol, Valine, Creatinine and Cystatin C
por: Stämmler, Frank, et al.
Publicado: (2021)

Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence?
por: Sarkar, S., et al.
Publicado: (2016)

Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
por: da Fonseca, Gisele da Silva, et al.
Publicado: (2021)

THE GLOMERULAR MESANGIUM : III. ACUTE IMMUNE MESANGIAL INJURY: A NEW MODEL OF GLOMERULONEPHRITIS
por: Mauer, S. Michael, et al.
Publicado: (1973)

Sirolimus Enhances Cyclosporine A-Induced Cytotoxicity in Human Renal Glomerular Mesangial Cells
por: O'Connell, Séin, et al.
Publicado: (2012)

Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells
por: Barati, Michelle T., et al.
Publicado: (2016)

Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence
por: Feng, Xin, et al.
Publicado: (2017)

Polyethylene Glycol 3350 Crystal Nephropathy in Association With Glomerular Mesangial Immunoglobin A Deposition
por: Aly, Rasha, et al.
Publicado: (2022)

Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population
por: Lujambio, Inés, et al.
Publicado: (2014)

Estimated glomerular filtration rate by serum creatinine or standardized cystatin C in Japanese patients with Graves׳ disease
por: Suzuki, Yoshitake, et al.
Publicado: (2015)

Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis
por: Dumnicka, Paulina, et al.
Publicado: (2022)

Serum creatinine and estimated glomerular filtration rate (eGFR) in early pregnancy and changes during the pregnancy
por: Agampodi, Suneth Buddhika, et al.
Publicado: (2023)

Overlap of Thrombotic Microangiopathy and Mesangial Proliferative Glomerulonephritis Caused by Combination Therapy with Atezolizumab and Bevacizumab
por: Horino, Taro, et al.
Publicado: (2022)

Differential expression profile of urinary exosomal microRNAs in patients with mesangial proliferative glomerulonephritis
por: Dai, Rong, et al.
Publicado: (2023)

Impact of creatinine methodology on glomerular filtration rate estimation in diabetes
por: Lovrenčić, Marijana Vučić, et al.
Publicado: (2017)

Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose
por: Saijun, Zhou, et al.
Publicado: (2018)

Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative features
por: Komatsuda, Atsushi, et al.
Publicado: (2010)

TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways
por: Soni, Hitesh, et al.
Publicado: (2016)

Suppression of Adiponectin by Aberrantly Glycosylated IgA1 in Glomerular Mesangial Cells In Vitro and In Vivo
por: Inoue, Tatsuyuki, et al.
Publicado: (2012)

Clinical significance of IgG deposition in the glomerular mesangial area in patients with IgA nephropathy
por: Wada, Yukihiro, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_abuehrkc4qgrn99dt1d25msobm