Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

Microglia are resident macrophages of the central nervous system, and their unique molecular signature is dependent upon CSF-1 signaling. Previous studies have demonstrated the importance of CSF-1R in survival and development of microglia in animal models, but the findings are of uncertain relevance...

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Detalles Bibliográficos
Autores principales: Kempthorne, Liam, Yoon, Hyejin, Madore, Charlotte, Smith, Scott, Wszolek, Zbigniew K., Rademakers, Rosa, Kim, Jungsu, Butovsky, Oleg, Dickson, Dennis W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236286/
https://www.ncbi.nlm.nih.gov/pubmed/32430064
http://dx.doi.org/10.1186/s40478-020-00947-0

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