Ipa1 Is an RNA Polymerase II Elongation Factor that Facilitates Termination by Maintaining Levels of the Poly(A) Site Endonuclease Ysh1

The yeast protein Ipa1 was recently discovered to interact with the Ysh1 endonuclease of the prem-RNA cleavage and polyadenylation (C/P) machinery, and Ipa1 mutation impairs 3′end processing. We report that Ipa1 globally promotes proper transcription termination and poly(A) site selection, but with...

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Detalles Bibliográficos
Autores principales: Pearson, Erika L., Graber, Joel H., Lee, Susan D., Naggert, Kristoph S., Moore, Claire L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236606/
https://www.ncbi.nlm.nih.gov/pubmed/30759400
http://dx.doi.org/10.1016/j.celrep.2019.01.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236606/
https://www.ncbi.nlm.nih.gov/pubmed/30759400
http://dx.doi.org/10.1016/j.celrep.2019.01.051

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