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The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges

Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that sustains proteostasis network under a large variety of physiopathological conditions. Its dysregulation is often associated with the onset and progression of human diseases; hence, UPS modulation has emerged as a promisin...

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Detalles Bibliográficos
Autores principales: Tundo, G.R., Sbardella, D., Santoro, A.M., Coletta, A., Oddone, F., Grasso, G., Milardi, D., Lacal, P.M., Marini, S., Purrello, R., Graziani, G., Coletta, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236745/
https://www.ncbi.nlm.nih.gov/pubmed/32442437
http://dx.doi.org/10.1016/j.pharmthera.2020.107579