Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

BACKGROUND: HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease inhibitors are found in the protease’s active site tha...

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Detalles Bibliográficos
Autores principales: Bastys, Tomas, Gapsys, Vytautas, Walter, Hauke, Heger, Eva, Doncheva, Nadezhda T., Kaiser, Rolf, de Groot, Bert L., Kalinina, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236880/
https://www.ncbi.nlm.nih.gov/pubmed/32430025
http://dx.doi.org/10.1186/s12977-020-00520-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236880/
https://www.ncbi.nlm.nih.gov/pubmed/32430025
http://dx.doi.org/10.1186/s12977-020-00520-6

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