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Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
BACKGROUND: HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease inhibitors are found in the protease’s active site tha...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236880/ https://www.ncbi.nlm.nih.gov/pubmed/32430025 http://dx.doi.org/10.1186/s12977-020-00520-6 |