Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity

Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), the cause of Huntington’s disease (HD), disrupts circadian rhythms often before motor symptoms are evident. Yet little is known about the molecular mechanisms by which mHt...

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Detalles Bibliográficos
Autores principales: Xu, Fangke, Kula-Eversole, Elzbieta, Iwanaszko, Marta, Hutchison, Alan L., Dinner, Aaron, Allada, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237104/
https://www.ncbi.nlm.nih.gov/pubmed/30943415
http://dx.doi.org/10.1016/j.celrep.2019.03.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237104/
https://www.ncbi.nlm.nih.gov/pubmed/30943415
http://dx.doi.org/10.1016/j.celrep.2019.03.015

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