HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner

Huntington’s Disease (HD) is a monogenetic neurodegenerative disorder mainly caused by the cytotoxicity of the mutant HTT protein (mHTT) encoded by the mutant HTT gene. Lowering HTT mRNA has been extensively studied as a potential therapeutic strategy, but how its level is regulated endogenously has...

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Detalles Bibliográficos
Autores principales: Zhao, Quan, Li, Chen, Yu, Meng, Sun, Yimin, Wang, Jian, Ma, Lixiang, Sun, Xiaoli, Lu, Boxun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237150/
https://www.ncbi.nlm.nih.gov/pubmed/31928144
http://dx.doi.org/10.1080/15476286.2020.1712894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237150/
https://www.ncbi.nlm.nih.gov/pubmed/31928144
http://dx.doi.org/10.1080/15476286.2020.1712894

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