β spectrin-dependent and domain specific mechanisms for Na(+) channel clustering

Previously, we showed that a hierarchy of spectrin cytoskeletal proteins maintains nodal Na(+) channels (Liu et al., 2020). Here, using mice lacking β1, β4, or β1/β4 spectrins, we show this hierarchy does not function at axon initial segments (AIS). Although β1 spectrin, together with AnkyrinR (AnkR...

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Detalles Bibliográficos
Autores principales: Liu, Cheng-Hsin, Seo, Ryan, Ho, Tammy Szu-Yu, Stankewich, Michael, Mohler, Peter J, Hund, Thomas J, Noebels, Jeffrey L, Rasband, Matthew N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237202/
https://www.ncbi.nlm.nih.gov/pubmed/32425157
http://dx.doi.org/10.7554/eLife.56629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237202/
https://www.ncbi.nlm.nih.gov/pubmed/32425157
http://dx.doi.org/10.7554/eLife.56629

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