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Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice
Meiotic crossovers result from homology-directed repair of DNA double-strand breaks (DSBs). Unlike yeast and plants, where DSBs are generated near gene promoters, in many vertebrates DSBs are enriched at hotspots determined by the DNA binding activity of the rapidly evolving zinc finger array of PRD...
Autores principales: | Mahgoub, Mohamed, Paiano, Jacob, Bruno, Melania, Wu, Wei, Pathuri, Sarath, Zhang, Xing, Ralls, Sherry, Cheng, Xiaodong, Nussenzweig, André, Macfarlan, Todd S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237205/ https://www.ncbi.nlm.nih.gov/pubmed/32352380 http://dx.doi.org/10.7554/eLife.53360 |
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