Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

Progressive telomere shortening during lifespan is associated with restriction of cell proliferation, genome instability and aging. Apoptosis and senescence are the two major outcomes upon irreversible cellular damage. Here, we show a transition of these two cell fates during aging of telomerase def...

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Detalles Bibliográficos
Autores principales: El Maï, Mounir, Marzullo, Marta, de Castro, Inês Pimenta, Ferreira, Miguel Godinho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237213/
https://www.ncbi.nlm.nih.gov/pubmed/32427102
http://dx.doi.org/10.7554/eLife.54935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237213/
https://www.ncbi.nlm.nih.gov/pubmed/32427102
http://dx.doi.org/10.7554/eLife.54935

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