Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting

Merkel cell polyomavirus (MCV) small T (sT) is the main oncoprotein in Merkel cell carcinoma (MCC) development. A unique domain of sT, LT stabilization domain (LSD), has been reported to bind and inactivate multiple SCF (Skp1-Cullin-F-box) E3 ligases. These interactions impede the turnover of MCV la...

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Detalles Bibliográficos
Autores principales: Nwogu, Nnenna, Ortiz, Luz E., Kwun, Hyun Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237485/
https://www.ncbi.nlm.nih.gov/pubmed/32427880
http://dx.doi.org/10.1038/s41389-020-0235-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237485/
https://www.ncbi.nlm.nih.gov/pubmed/32427880
http://dx.doi.org/10.1038/s41389-020-0235-y

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